It's a bad idea to use mirroring and rotation when creating glyphs. The reason is that it ties the correct interpretation of a string to its position and orientation in space. Generally we want meaning to be absolute. The meaning of a string shouldn't change depending on your position relative to it: if you fire a Latin 'b' into space, it's impossible to tell whether you meant 'b','q','p', or 'd'. The problem is worse with the alphabet in the article.

In case you were wondering, the symmetry of the shapes does not allow any interesting logical operations to be performed by reorienting the string in space, except as it happens by accident.

Fascinating diagram and layout, but damn that's got to be tough on dyslexics.